Informations P136
Info for health care providers
P88 vs. P136 – What’s the same? What’s the difference?
The P136 provides an even more precise picture of a patient's immune responses to food.
As with the P88, IgE and IgG4 antibodies are measured to assess both allergic reactions and the development of tolerance. In contrast, however, the P136 does not measure total IgG antibodies; instead, it specifically determines the subclasses IgG1 through IgG3, which are relevant for sensitivities.
The P136 also offers expanded diagnostic capabilities in the area of the complement system: The complement fragment C3d, previously measured in the P88, is supplemented by C4d, ensuring that all three activation pathways of the complement system are taken into account. In addition, the antibodies IgA1 and IgA2 are included in the assessment.
Symptoms associated with reactions to food:
- Constipation or diarrhea
- Refulx
- Rash, eczema, hives
- Recurrent infections
- Depressions
- Migraine
- Flatulence
- Poor absorption of vitamins, etc.
- Joint pain
- Exhaustion, poor sleep
- Weight gain
- Autoimmune diseases
Was wird beim P136 getestet?
Unser Immunsystem schützt unseren Körper vor äußeren Angriffen und körperfremden Strukturen. Bei Lebensmittel-Allergien und -Sensitivitäten reagiert das Immunsystem fälschlicherweise auf bestimmte Lebensmittel mit der Bildung von Abwehrstoffen. Der P136 Lebensmittel-Antigen-Test misst alle relevanten Immunreaktionen:
IgE is responsible for Type 1 immediate allergic reactions. Measuring IgG4 at the same time allows for an assessment of the extent to which immune tolerance exists.
IgG subtype 4 differs fundamentally from IgG1, IgG2, and IgG3. IgG4 reduces histamine release during an IgE-mediated immediate-type reaction through competitive inhibition of the receptor and has little pro-inflammatory effect itself. This mechanism is utilized in desensitization. This process does not reduce IgE levels; rather, it stimulates the production of IgG4. When the absolute serum IgG4 level is higher than the serum IgE level, IgG4 protects against an immediate allergic reaction. Immune tolerance is achieved.
In practice, it has been shown that IgG measurements alone often do not accurately reflect a patient’s actual symptoms. The combined measurement of IgG and complement is superior to measuring IgG alone, as activation of the complement system amplifies the immune response many times over.
The complement system enzyme cascade serves as the link between innate and adaptive immune defenses. Complement components themselves can trigger mast cell degranulation and enhance antibody responses, independent of IgE. By measuring C3d and C4d, all three complement activation pathways—the classical pathway, the lectin pathway, and the alternative pathway—are taken into account.
Unlike IgG4, only IgG1–3 antibodies bind to complement. Determining the relevant IgG subtypes—excluding IgG4—therefore yields more precise results.
Complement activation plays a key role in many diseases. When foods are eliminated based on both IgG and complement levels, symptoms subside more quickly.
The P136 is the only test that identifies IgA subtypes. IgA1 and IgA2 account for 15% of total antibody production.
Serum IgA testing is used to assess reactions to foods. IgA is produced in response to antigens that cross the intestinal barrier and may rise gradually (after several days). Elevated levels may indicate a compromised intestinal mucosa (“leaky gut”).
Combined testing for IgA and IgG is recommended to identify as many food intolerances as possible and avoid false-negative results. Based on the results, a targeted elimination diet can be developed.
IgA1 and IgA2, together with IgG4 and IgE, as well as IgG1–3 and complement C3d/C4d, complete the picture regarding immune responses to food.
Wie kann ich den P136 DIY bestellen?
Sie sind TherapeutIn? Sobald Sie sich regeistriert haben können Sie den P136 DIY in Ihre Praxis oder direkt für einen Patienten bestellen,
Are you a patient without a practitioner? Contact us — we’ll be happy to help!
